PT 20210A
Turner's Syndrome

The Lupus Connection

Anti Phospholipid Syndrome

 Anti Phospholipid
Syndrome (APS) research



  • Up to 50% of patients with SLE have antibodies to phospholipids ('sticky blood').
  • SLE patients with Antiphospholipid antibodies: 40% have thrombosis.
  • SLE without Antiphospholipid antibodies: 12% to 18% of patients.
  • SLE patients have a higher incidence of cardiac valvular disease, hemolytic anemia, leukopenia and low C4 complement levels.
  • Hemorrhagic stroke occurs more commonly in active lupus.
  • Thrombotic stroke, possibly related to the Anti-phospholipid antibody, is more common in quiescent phases-(remissions).
  • Prevalence Of Antiphospholipid Antibodies:

    Presence of antiphospholipid antibodies does not necessarily indicate an increased risk for thrombosis.
    The presence of AP-As is considered a risk factor for stroke, but this association may be true only in patients with SLE or other autoimmune disorders.
    Many well-controlled studies have found no association between AP-As and stroke in non-SLE patients.

    Autoimmune diseases Percentage Relationships to Secondary Anti-Phospholipid Syndrome (APS)

    • Juvenile chronic arthritis - 55%
    • SLE - 15% to 50%
    • Sjogren's syndrome - 42%
    • Rheumatoid arthritis - up to 33%
    • Idiopathic Thrombotic Purpura - 30%
    • Posoriatic arthritis - 28%
    • Scleroderma - 25%
    • Mixed Connective Tissue Disease - 22%
    • Giant cell arteritis - 20%
    • Polymyalgia rheumatica - 20%
    • Behcet's disease - 0% to 50%

    Treatment to prevent Thrombosis

  • Treatment of patients with APL Antibody is controversial.
    The problem seems to be mainly an abnormal hyper-coagulable state that predisposes to thrombosis of arteries rather than true vasculitis.
    Asymptomatic patient with Antiphospholipid Antibodies: Reduce risk factors for vascular disease.
    Patients with high titers: Avoid oral contraceptive.
    Life style change: Maintain ideal weight, cholesterol level and physical activity; control blood pressure and avoid smoking.

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